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Generic Name: Lysergic acid diethylamide (LSD)
Common or street names: LSD is sold under more than 80 street names including Acid, Blotter, acid, Doses, Dots, Trips, Mellow Yellow, Window Pane, as well as names that reflect the designs on sheets of blotter paper (for example, “purple dragon”).

What is LSD?

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LSD (lysergic acid diethylamide), first synthesized in 1938, is an extremely potent hallucinogen. It is synthetically made from lysergic acid, which is found in ergot, a fungus that grows on rye and other grains. It is so potent its doses tend to be in the microgram (mcg) range. It’s effects, often called a “trip”, can be stimulating, pleasurable, and mind-altering or it can lead to an unpleasant, sometimes terrifying experience called a “bad trip.”

In the U.S., LSD is illegal and is classified by the Drug Enforcement Agency (DEA) as a Schedule 1 drug, meaning LSD has a high potential for abuse, has no currently accepted medical treatments, and has a lack of accepted safety for use under medical supervision. However, despite being a Schedule 1 substance, there has been a resurgence of interest in potential therapeutic uses for LSD, such as for the treatment of alcoholism and depression. Studies that conform to modern research standards are currently underway that might strengthen our knowledge on the use of LSD.

LSD is produce in crystalline form and then mix with other inactive ingredients, or dilute as a liquid for production in ingestible forms. It is odorless, colorless and has a slightly bitter taste.

LSD is usually found on the streets in various forms, for example:

• blotter paper (LSD soaked onto sheets of absorbent paper with colorful designs; cut into small, individual dosage units) – the most common form
• thin squares of gelatin (commonly referred to as window panes)
• tablet form (usually small tablets known as Microdots) or capsules
• liquid on sugar cubes
• the pure liquid form (maybe extremely potent)

Some people may inhale LSD through the nose (snort) or inject it into a vein (shoot it up). There is no way to predict the amount of LSD that is contained in any form consumed.

Other hallucinogens include:

• Psilocybin (Magic Mushrooms, Shrooms)
• Mescaline (Peyote, Buttons, Cactus)
• Phencyclidine (PCP, Angel Dust)
• Ayahuasca (DMT)
• Salvia divinorum (salvia)

Effects of LSD Use

LSD is a mind-altering drug. It is thought LSD causes it’s characteristic hallucinogenic effects via interaction with the serotonin receptors in the brain. Serotonin is a neurotransmitter that helps control your behavior and mood, governs your senses, and moderates your thoughts.https://52defa9f08c305ce3a39b740dfe72926.safeframe.googlesyndication.com/safeframe/1-0-38/html/container.html

The physical effects of LSD are unpredictable from person-to-person. Usually, the first effects of the drug when taken by mouth are felt 30 to 45 minutes after taking it, peak at 2 to 4 hours, and may last 12 hours or longer. Use by the intravenous (IV) route will produce a much quicker action, usually within 10 minutes. Effects include:

• hallucinations
• distorted visual perception of shapes, colors
• altered sounds
• anxiety and depression
• flashbacks (a return of the “trip” experience) days or months later
• rapid heart rate, increased body temperature and high blood pressure
• dilated pupils

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Extreme changes in mood can occur. If taken in large enough doses, the drug produces delusions and visual hallucinations. Overdose can lead to severe psychosis. Death is often due to a direct injury while under LSD influence; there is no known lethal dose of LSD.

The physical effects can also include nausea, loss of appetite, increased blood sugar, difficulty sleeping, dry mouth, tremors and seizures.

The user may also experience impaired depth and time perception, with distorted perception of the size and shape of objects, movements, color, sound, touch and their own body image. Sensations may seem to “cross over,” giving the feeling of hearing colors and seeing sounds. These changes can be frightening and can cause panic. Some LSD users also experience severe, terrifying thoughts and feelings, fear of losing control, and fear of insanity or death.

An experience with LSD is referred to as a “trip”. Acute, disturbing psychological effects are know as a “bad trip”. These experiences are lengthy, with the effects of higher doses lasting for 6 to 12 hours, and it may take 24 hours to return to a normal state.

Health Hazards and Flashbacks with LSD

Under the influence of LSD, the ability to make sensible judgments. And see common dangers is impaired, making the user susceptible to personal injury or death.

After an LSD trip, the user may suffer acute anxiety or depression, and may also experience flashbacks (also called hallucinogen persisting perception disorder). Which are recurrences of the effects of LSD days or even months after taking the last dose.

• A flashback occurs suddenly, often without warning, usually in people who use hallucinogens chronically or have an underlying personality problem.
• Healthy people who only use LSD occasionally may also have flashbacks.
• Bad trips and flashbacks are only part of the risks of LSD use. LSD users may also manifest relatively long-lasting psychoses, such as schizophrenia or severe depression.

LSD produces tolerance, meaning the user needs greater doses of LSD to get the same high. Some users who take the drug repeatedly must take progressively higher doses to achieve the state of intoxication that they had previously achieved. This is an extremely dangerous practice, given the unpredictability of the drug.

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The National Survey on Drug Use and Health (NHSDA) in 2018 estimated that 5.6 million people aged 12 or older were past year users of hallucinogens (which includes LSD, PCP, peyote, mescaline, psilocybin mushrooms, Ecstasy, ketamine, DMT/AMT/“Foxy,” and Salvia divinorum), corresponding to 2% of the population.

The percentage of people aged 12 or older in 2018 who were past year hallucinogen users was higher than the percentages in 2015 and 2016, but it was similar to the percentage in 2017.

Rates of LSD use remain low among youth in the U.S. In 2018, it was estimate that 376,000 adolescents aged 12 to 17 were past-year users of hallucinogens. Which corresponds to about 1.5% of adolescents. The percentage of adolescents in 2018 who were past year hallucinogen users was lower than the percentages in 2015 and 2017, but it was similar to the percentage in 2016.

In 2019, based on data from NIDA’s Monitoring the Future 2019 Survey Results: Overall Findings, past year illicit drug use for LSD among surveyed 12th graders was 3.6%, far below illicit drug use for marijuana, which stood at 35.7%. 

Between the years 2015 to 2016, trends in annual prevalence of use of LSD for Grades 8, 10, and 12 combined were 1.9% (2015) and 2.0% (2016), a +0.1 points percentage increase. The Monitoring the Future National Survey Results on Drug Use: 2016 Overview. Key Findings on Adolescent Drug Use found that “generational forgetting” — students stating that they are not familiar with the drug — has resulted in a decline in perceived risk of LSD among younger groups, which may put them at higher risk of use in future years. This points to the need for continued education over time on all illicit drugs (including hallucinogens) that may be a risk for youth.

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Once a decision is make to obtain treatment, there are several steps to take.

• Speak to a healthcare provider to help direct you to reliable sources of help and monitor your progress.
• Talk therapy (behavioral counseling) and group counseling may be an option to help you understand your behaviors and why you continue to use LSD.
• Keep your appointments and follow your providers’ treatment plan. Consider including trusted family or friends in your treatment plan.
• Take care of yourself: exercise, eat healthfully and control your stress level. Surround yourself with supportive people.
• Added medical therapy may need to treat symptoms due to drug use, such as anxiety, depression, or schizophrenia.
• Work to find new hobbies and interests that will take your mind off of drug use. Consider a volunteer opportunity.
• Each day makes an effort to stay away from people who abuse drugs, even if they are former friends.

Effects on perception

LSD can trigger a range of perceptual changes, often relating to vision, touch, emotions and thinking.

Visual effects include brightened, vivid colors, blurred vision, distorted shapes and colors of objects and faces, and halos of light.

Changes related to touch include shaking, pressure, and lightheadedness.

Mood changes can lead to a sense of euphoria, bliss, peacefulness, dreaminess, and heightened awareness, or despair, anxiety, and confusion. There may be rapid mood swings.

Impact on thinking can lead to a distorted perception of time, either fast or slow, accelerated thoughts, unusual insight or terrifying thoughts, and a sense of transcendence.

LSD is colorless and odorless. A very small amount, equivalent to two grains of salt, is sufficient to produce the drug’s effects.

It is taken orally as capsules, pills, sugar cubes, chewing gum, or liquid drops transferred to colorful blotter paper. Recreational dosage averages between 25 to 80 micrograms (mcg).

The onset of hallucinations occurs within 60 minutes, and it can last from 6 to 12 hours.

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Physical stimulation resulting from LSD use causes the pupils to dilate, and blood pressure, heart rate, and temperature to rise.

Other short-term effects include:

• dizziness and sleeplessness
• reduced appetite, dry mouth, and sweating
• numbness, weakness, and tremors

However, it primarily affects the mind with visual distortions and sensory hallucinations and illusions.

The danger lies in the unpredictability of the “trip.” The potency of the drug is unreliable, and individuals react differently to it.

The user’s mindset, surroundings, stress level, expectations, thoughts, and mood at the time the drug is taken, strongly influence the effects of the drug.

Effects can include feelings of well-being, a perception of being outside one’s body, an enhanced insight towards creativity, problem-solving, discovering a purpose, and mystical experiences.

A “bad trip,” on the other hand, is like a living nightmare. It is similar to psychosis, and the person cannot escape from it. There may be extreme fear, paranoia, a separation from self, and the person may believe that they are dying or in hell.

It can also trigger panic attacks, psychotic episodes, disturbing anxiety, paranoia, pain, and a feeling of dying or going insane.

Severe or life-threatening physical effects are only likely to occur at doses above 400 mcg, but the psychological effects can lead to unusual and risky behavior, potentially resulting in significant injury and death.

As users have no control over the purity of the drug, it is difficult to predict the effect on the body and the mind.

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Tolerance, or a need to increase the dose to achieve the desired response, happens quickly. If a specific dose is taken every day for 3 consecutive days, by the third day no reaction will occur.

LSD is not physically addictive, so physical withdrawal symptoms do not occur after stopping use, but psychological addiction can develop.

One of the dangers is that LSD can trigger a long-term psychotic state or induce schizophrenia in susceptible individuals.

Flashbacks, also known as hallucinogen persisting perception disorder (HPPD), and severe disorientation can happen after only one dose.

The reasons for this are unknown.

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